Analysis of polymorphisms in recurrent pregnancy loss: Factor V Leiden G1691A, Factor II G20210A, MTHFR C677T and Factor V H1299R

The distribution of factor V Leiden G1691A, II G20210A, MTHFR C677T, and H1299R polymorphisms known to predispose thrombophilia in 215 cases 40 controls admitted with indication recurrent pregnancy loss (RPL) was investigated. Genotyping performed by melting curve analysis using simultaneous PCR (RT-PCR). There no difference between genotype allele frequencies the case control groups terms examined (p>0.05). In Factor gene G1691A polymorphism, 12.6% GA group 90.0% GG (wild) genotypes were found be higher than other genotypes. G20210A 94.5% 97.5%, respectively, C677T 43.7% CC 40.0% CT A4070G 87.4% AA 80% However, frequency risk A for (6.8% 5%), (3% 1.2%), determined groups. T (35.9% 42.5%), which is A4070G, G (6.5% 16.6%), determined. When our study results evaluated, relationship RPL polymorphisms.